Daymar College has a rich business education history. When it first opened its doors as Owensboro Business College in 1963, the main academic focus was on general business studies. Two years later, secretarial science and accounting were added.

In 1970, the College was nationally accredited as a business college by the Accrediting Commission of the Association of Independent Colleges and Schools and was approved by the United States Department of Education to award financial aid to students.

The College began offering all programs on a credit-hour basis and was authorized by the Kentucky State Board for Proprietary Education to award Associate degrees in 1973. The United States Office of Education awarded the College a Special Services project, making it the first private career college to receive such an honor.

The name was changed in August of 2001 from Owensboro Junior College of Business to Daymar College.